The goal of the RENEW Team is to Recovery through ENgaging and Empowering Women. With our DMPA project, we are exploring the use of DMPA (depot medroxyprogesterone acetate, commonly known as depo provera) to help women quit smoking. Tobacco use, mostly cigarette smoking, is estimated to cause 1 out of every 3 cancers. This is of concern for women, given they are more susceptible to the harmful effects of smoking than men. Most smoking cessation medications (such as the nicotine patch) are less effective in women compared to men. Ovarian hormones (notably estradiol) may be one of the reasons why women have a more difficult time quitting smoking than men. This project will preliminarily examine the effect of Depot medroxyprogesterone acetate to help women quit smoking.